In the various cellular events of inflammation,
Rolling is due to selectins
Adhesion is due to integrins
LAD 1:
LAD1 is due to defect in β2 integrins.
Characterised by persistent leucocytosis, delayed separation of umbilical cord and recurrent infections
LAD 2:
LAD 2 is due to deficiency of Selectins
Characterised by recurrent infections
Can be associated with Bombay Blood group